Dual PDE3/4 and PDE4 Inhibitors: Novel Treatments For COPD and Other Inflammatory Airway Diseases

Selective PDE4 inhibitors as potent anti-inflammatory drugs for the treatment of airway diseases.

Phosphodiesterases (PDEs) are responsible for the breakdown of intracellular cyclic nucleotides, from which PDE4 are the major cyclic AMP metabolizing isoenzymes found in inflammatory and immune cells. This generated greatest interest on PDE4 as a potential target to treat lung inflammatory diseases. For example, cigarette smoke-induced neutrophilia in BAL was dose and time dependently reduced ...

PDE4-targeted treatments for autoimmune diseases

Apremilast: a novel PDE4 inhibitor in the treatment of autoimmune and inflammatory diseases.

Phosphodiesterase 4 (PDE4) is a key enzyme in the degradation of cyclic adenosine monophosphate and is centrally involved in the cytokine production of inflammatory cells, angiogenesis, and the functional properties of other cell types such as keratinocytes. In this review article, apremilast, a novel small molecule inhibitor of PDE4, is introduced. Apremilast has profound anti-inflammatory pro...

EDITORIAL: INFLAMMATORY AIRWAY DISEASES AND CLINICAL ALLERGY ASSEMBLY Inflammatory airway diseases and clinical allergy

A ssembly 5 of the European Respiratory Society (ERS) is the Inflammatory Airway Diseases and Clinical Allergy Assembly and consists of three Scientific Groups: 1) Airway Pharmacology and Treatment; 2) Monitoring Airway Diseases; and 3) Allergy and Immunology. The original focus of the Assembly was mostly on asthma, but in recent years, it has increasingly begun to encompass chronic obstructive...

Development status of second generation PDE4 inhibitors for asthma and COPD: the story so far.

The beginning of the 1990s saw the synthesis and evaluation of orally-active, second generation phosphodiesterase (PDE) inhibitors that have high specificity for the PDE4 subtype. In vitro and in vivo studies established that this class of compounds suppresses the activity of many pro-inflammatory and immune cells indicating that they may be effective in the treatment of airway inflammatory dis...